23.04.2025
admissions
Erik Abner
PhD
Institute of Genomics
Estonian Genome Centre
Research Fellow of Functional Genomics
+372 737 4029
Riia 23b/2-412

PhD position: Genetic basis of host susceptibility to respiratory viruses and chronic respiratory diseases

FunGen group 2025 april
Author: Andres Tennus

Research project: Genetic basis of host susceptibility to respiratory viruses and chronic respiratory diseases

About the project:

The aim of this doctoral research project is to elucidate the genetic background of chronic respiratory diseases (CRDs), with a focus on the interplay between respiratory viral infections and host genetics. By leveraging health and genetic data from the Estonian Biobank and nasopharyngeal swab collections, this study seeks to identify genetic risk factors for viral infections and their role in disease pathogenesis.

Preliminary analyses have identified promising genetic variants involved in the regulation of lung inflammatory responses, which may mediate the development of RSV bronchiolitis and chronic lung diseases. This project employs bioinformatic methodologies to map the genetic mechanisms of CRDs and their interactions with viral infections. The analysis focuses on the interplay between genetic predisposition and environmental influences, particularly viral infections, in disease development. Additionally, it aims to identify genetic and phenotypic overlaps among chronic lung diseases to distinguish underlying molecular mechanisms and define both shared and disease-specific pathogenic factors. To understand the interplay between host genetics and viral infections, the project will integrate phenotypic and genetic data from viral infection datasets, analyzing correlations between genetic predispositions and infection patterns. RNA sequencing will also be carried out to identify viral strains from nasal swab samples, enabling detailed analyses of how specific viral strains interact with host genetics. These comprehensive approaches will provide insights into the genetic and environmental factors contributing to the development and progression of CRDs in the context of viral infections.

The findings from this research will advance our understanding of the links between infectious diseases and chronic conditions, paving the way for personalized prevention strategies and targeted therapeutic interventions.

Supervisors:
Dr Erik Abner, Prof Elin Org

Who we are:

The Functional Genomics research group explores how human genetic variation drives molecular and phenotypic diversity. We integrate bioinformatics, population-scale genetic data, and molecular trait measurements to map the mechanisms underlying complex traits and disease. Our focus spans endophenotype QTL mapping, rare variant analysis, and the interplay between genetic and environmental factors.

More about us: https://genomics.ut.ee/en/content/estonian-genome-centre

What we expect from the applicant:

  • Master’s degree in a relevant field such as bioinformatics, genetics, genomics, molecular biology, immunology, or microbiology.
  • Strong interest in human health, infectious diseases and chronic disease genetics.
  • Solid skills in bioinformatics or data analysis. Laboratory experience is beneficial but not mandatory.
  • English proficiency at B2 level or higher (written and spoken).

What we offer:

  • A place in our international team of researchers working at the forefront of functional genomics.
  • An opportunity to work with one of the world's most comprehensive biobank datasets and gain experience in large-scale genomic data analysis.
  • Access to the University of Tartu High Performance Computing Center (UT HPC) and modern bioinformatics tools.
  • A friendly, supportive, and collaborative research environment with excellent opportunities for personal and professional growth.
  • Opportunities for collaboration with leading international partners and participation in scientific conferences and workshops.

What is needed to apply:

  • Motivation letter (see guidelines under the application link below).
  • Curriculum vitae (see relevant form under the application link below)
  • Official copies of both bachelor’s and master’s diplomas and diploma supplements (transcripts) in the original language.
  • Official translations of the diplomas and diploma supplements into English (if not present in the originals).
  • Proof of English language proficiency at a satisfactory level (B2).
  • Copy of the passport page stating the applicant’s personal particulars.

Application period: 1st–15th May 2025

Apply here!

Start date of studies: 1st September 2025

Get familiar:

Contact: Do not hesitate to contact the main supervisor Erik Abner ([email protected]) with any enquiries regarding the project or the group, and Merilin Raud ([email protected]) with general enquiries about PhD studies in the institute.