Research Group for Developmental Genetics and Neurobiology

Research Group for Developmental Genetics and Neurobiology addresses two interrelated topics. One aim is to find out how genetic changes associated with autism spectrum disorders affect the development and function of cerebellar cells. Autism spectrum disorders affect approximately 1% of people worldwide, causing lifelong difficulties in social interactions, communication, and behaviour.

Secondly the group is studying the evolution of the cerebellum, which has historically been an overlooked topic compared to the research on the evolution of the cerebral cortex. The development of human cognitive abilities has often been associated with the expansion of the cerebral cortex. Studies have shown that the cerebellum also played a significant role in this process, increasing during human evolution.

Mari Sepp
Mari Sepp received her doctorate from Tallinn University of Technology in 2012 and is currently a postdoctoral fellow at Heidelberg University. In her doctoral thesis, she studied the roles of a transcription factor (TCF4) associated with autism and schizophrenia in nerve cells under the supervision of Professor Tõnis Timmusk. At Heidelberg University, she works in Professor Henrik Kaessmann's research group, where she leads a research direction focusing on the development and evolution of the mammalian cerebellum. The main focus is on gene expression and regulation. Sepp has received scientific awards and recognition in Estonia, the USA and Germany.